Welcome to the LuxExpats Interview Series! Today, we speak with Prof. Rejko Kruger, a leading expert in neuroscience and dementia prevention, about how tools like the PDP Braincoach App are revolutionizing brain health!
Luxembourg Expats: Professor KRÜGER, welcome to the Luxembourg Expats interview series. Luxembourg Expats is a community for expats in Luxembourg. We bring together local businesses, services, and people for a happier and easier life in Luxembourg, reaching about 100,000 expats through our various channels. We are delighted to welcome you to the interview series. Today, we are going to talk about yourself, dementia, and also the Brain Coach app. Welcome!
Professor Rejko KRÜGER: Thank you very much. My name is Rejko KRÜGER. I'm a neurologist by training, and I came to Luxembourg more than 10 years ago as a professor for clinical and experimental neuroscience. In the meantime, I’m also the Director for Transversal Translational Medicine at the Luxembourg Institute of Health. My work allows me to focus on neurodegenerative diseases and movement disorders, creating a translational pipeline that connects fundamental research, clinical research, clinical studies, integrated healthcare, and prevention of neurodegenerative diseases.
Luxembourg Expats: That’s fantastic. So, 10 years ago, you joined Luxembourg. You are part of the expat community here. Before we jump into your work, tell us how Luxembourg happened at that time.
Professor Rejko KRÜGER: It was an opportunity to come to Luxembourg. You may know that the research environment here is still developing, and the university was quite new at that time. In fact, I’ve accompanied almost half of the University of Luxembourg’s lifespan, as it’s just over 20 years old now. At that time, Professor Rudi Balling had founded the Luxembourg Centre for Systems Biomedicine, and he needed someone to connect research to healthcare, ensuring that discoveries could impact patient care. I found that challenge very attractive. At the time, I was working in Tübingen, Germany, at the university clinic and the Hertie Institute for Clinical Brain Research. The opportunity to bring academic knowledge into a developing medical education and healthcare system in Luxembourg was compelling.
Luxembourg Expats: So, you’ve been part of this development alongside the university. What have been the key developments over the last 10 years since you joined?
Professor Rejko KRÜGER: The major development has been creating an interdisciplinary spirit and inter-institutional collaboration, which generated critical mass around key topics. At the time, we were able to establish the National Centre for Excellence in Research on Parkinson’s Disease, funded by the national funding agency. This brought together the University of Luxembourg, the Luxembourg Institute of Health, the Laboratoire National de Santé, the Integrated Biobank of Luxembourg, and hospitals like the CHL, where we founded the first Parkinson’s Research Clinic. This initiative invited people with Parkinson’s and healthy controls from Luxembourg and the greater region to join our research. This collaboration became a model for advancing other diseases and research areas.
Luxembourg Expats: That’s incredible. Silos are a common challenge in research. It’s great to hear how integration can lead to meaningful results. Today, we’re going to talk about dementia and the Brain Coach app. Can you tell us about the origins of the app and how it came about?
Professor Rejko KRÜGER: Certainly. To give some context, the National Centre for Excellence in Research allowed us to advance our understanding of neurodegenerative diseases. However, we always aimed to impact everyday healthcare experiences. One significant initiative was piloting an integrated care network for Parkinson’s Disease, called ParkinsonNet, benchmarked from the Netherlands. This evolved into an integrated neurodegenerative disease management system in Luxembourg. I’ve also been coordinating the National Dementia Plan, focusing on prevention. We invite people with mild cognitive impairments to undergo neuropsychological assessments and map their individual risk factors. Research has identified 14 modifiable risk factors for dementia. Addressing these could prevent up to 45% of all cases.
The Brain Coach app emerged as a tool to act earlier. Many of these risk factors are best addressed in midlife. We partnered with Maastricht University in the Netherlands to adapt their Brain Coach app to Luxembourg. It’s available in French, German, and English, and provides a personalized approach to raising awareness and encouraging small, impactful lifestyle changes. The app is free and available on Google Play and the App Store.
Luxembourg Expats: That’s impressive. Let’s take a step back. Talk to us about dementia—the scale of the problem globally and in Luxembourg. When should someone start thinking about it?
Professor Rejko KRÜGER: Dementia is a global challenge. As we age, the risk of neurodegenerative diseases like dementia and Parkinson’s increases. Globally, the number of people affected is growing. For example, the number of people with Parkinson’s will double in the next 20 years, and Alzheimer’s cases are also on the rise. Early signs of dementia often include forgetfulness. We encourage anyone with concerns to talk to their general practitioner, who can refer them to our dementia prevention program. This program provides neuropsychological testing and lifestyle recommendations to slow or prevent progression.
Luxembourg Expats: What age should people start thinking about prevention? Is it in their 30s, 40s, or later?
Professor Rejko KRÜGER: Research shows that the processes leading to dementia often start 10 to 20 years before diagnosis. For example, Alzheimer’s can be detected through specific markers in cerebrospinal fluid or blood years before symptoms appear. This means prevention should begin in midlife. Education is a key modifiable risk factor. Longer formal education reduces dementia risk. Cognitive and social activities also help by building brain reserve capacity.
Luxembourg Expats: For someone new to the app, can you explain the user journey from signing up to daily use?
Professor Rejko KRÜGER: The app is personalized. Users start by entering their name and contact details, which are data-protected. They complete an initial questionnaire to map potential risk areas. Based on this, users receive daily “nuts,” which are tasks, quizzes, or challenges tailored to their profile. For example, users might be asked to cook a healthy recipe, go on a hiking tour, or learn about evaluating food labels. Each identified risk factor is addressed with 15 unique nuts. The app encourages small, impactful lifestyle changes.
Luxembourg Expats: What’s the current status of the app? Are people using it?
Professor Rejko KRÜGER: We’ve received positive feedback across language groups and are currently in a stepwise launch. We’re refining the app based on user feedback and plan to release revised versions as new research emerges. Each update will integrate the latest findings on modifiable risk factors.
Luxembourg Expats: Can you highlight a few modifiable risk factors?
Professor Rejko KRÜGER: Healthy eating is crucial, such as the Mediterranean or Northern European diets with more fish. Social integration is another key factor—attending events, going to the cinema, or engaging in group activities helps prevent dementia and combats depression, which is also a risk factor.
Luxembourg Expats: That’s fascinating. Thank you for sharing your insights and this impactful work. The Brain Coach app sounds like an excellent tool for promoting awareness and prevention.
🎥 Watch the Full Interview Here : youtu.be/JqJXGPY3CvQ?feature=shared
🧠 Learn More About The BrainCoach App Here : shorturl.at/3qCjn
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Keywords : Brain Coach app, Prof Rejko KRÜGER, dementia prevention, Luxembourg Expats, neurodegenerative diseases, Parkinson's research, National Dementia Plan, modifiable risk factors, healthy lifestyle, Mediterranean diet, social integration, personalized healthcare, Maastricht University, integrated care network, neuropsychological assessment, Alzheimer's prevention.